Determination of Oxidative Stress Level (malondialdehyde) and Some Antioxidant (superoxide Dismutase, Catalase and Reduced Glutathione) Activities in Patients With High Calcium Scores
Abstract
Bu tez çalışmasında Van YYÜ Dursun Odabaş Tıp Merkezi Radyoloji polikliniğinde yüksek kalsiyum skoru teşhisi konulmuş hastalardan alınan serum örneklerinden bazı antioksidant aktiviteleri (SOD, GSH ve CAT) ve lipid peroksidasyon ürünü olan MDA düzeyi araştırıldı. Yüksek kalsiyum skorlu hastalarda GSH için hasta ve kontrol grubunun ortalamaları arasındaki fark istatistik olarak anlamlı bulunmazken CAT, MDA ve SOD için hasta ve kontrol grubunun ortalamaları arasındaki fark istatistik olarak anlamlı bulunmuştur (p<0.05). Hasta grubun serum CAT aktivitesi kontrol grubuna göre anlamlı derecede daha düşük bulundu (p<0.05). Hasta grubu serum GSH seviyesi kontrol grubuna göre daha düşük bulundu ama istatistiksel olarak analamlı bulunmadı (p>0.05). Hasta serum MDA düzeyi kontrol grubuna göre anlamlı düzeyde daha yüksek bulundu (p<0.05). Sonuç olarak; SOD, CAT ve GSH aktivitelerinin kanda yüksek olması, yüksek kalsiyum skorlu hastalarda hastalık riskini azaltıcı bir faktör olarak değerlendirilebilir. Ayrıca, oksidatif stres ve antioksidan dengedeki herhangi bir hasarın, yüksek kalsiyum skoru gelişiminin hastalığının muhtemel bir nedeni olduğu düşünülebilir.
In this thesis study, some antioxidant activities (SOD, GSH and CAT) and the level of MDA, a lipid peroxidation product, were investigated from serum samples taken from patients diagnosed with high calcium scores in the Radiology Policlinic of Van YYÜ, Dursun Odabaş Medical Center. While the difference between the means of the patient and control groups for GSH in patients with high calcium scores was not statistically significant, the difference between the means of the patient and control groups for CAT, MDA and SOD was statistically significant (p<0.05). Serum CAT activity of the patient group was found to be significantly lower than the control group (p<0.05). Serum GSH level in the patient group was found to be lower than the control group, but not statistically significant (p>0.05). The patient serum MDA level was found to be significantly higher than the control group (p<0.05). As a result; High SOD, CAT, and GSH levels in the blood can be considered as a factor reducing the risk of disease in patients with high calcium scores. Moreover, oxidative stress and any damage to the antioxidant balance can be considered a possible cause of the disease of the development of high calcium scores.
In this thesis study, some antioxidant activities (SOD, GSH and CAT) and the level of MDA, a lipid peroxidation product, were investigated from serum samples taken from patients diagnosed with high calcium scores in the Radiology Policlinic of Van YYÜ, Dursun Odabaş Medical Center. While the difference between the means of the patient and control groups for GSH in patients with high calcium scores was not statistically significant, the difference between the means of the patient and control groups for CAT, MDA and SOD was statistically significant (p<0.05). Serum CAT activity of the patient group was found to be significantly lower than the control group (p<0.05). Serum GSH level in the patient group was found to be lower than the control group, but not statistically significant (p>0.05). The patient serum MDA level was found to be significantly higher than the control group (p<0.05). As a result; High SOD, CAT, and GSH levels in the blood can be considered as a factor reducing the risk of disease in patients with high calcium scores. Moreover, oxidative stress and any damage to the antioxidant balance can be considered a possible cause of the disease of the development of high calcium scores.
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Kimya, Chemistry
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