Inal, AliKoc, BoraBircan, Huseyin YuceOgan, EbruYavuz, AlpaslanKemik, Ozgur2025-05-102025-05-1020142325-44162325-439410.12659/MSMBR.8912392-s2.0-84924925208https://doi.org/10.12659/MSMBR.891239https://hdl.handle.net/20.500.14720/10670Yavuz, Alpaslan/0000-0002-8796-988X; Kemik, Ozgur/0000-0002-4612-1428; Bircan, Huseyin Yuce/0000-0001-8196-9195Background: Age-associated immune senescence is a catch-all phrase that has been used to describe a plethora of changes to the immune system across the lifespan. Aging is associated with a decline in immune function. Our aim in this study was to investigate how lymphocyte subgroups in peripheral blood are affected by aging among males and females. Material/Methods: Study participants were 70 healthy individuals from 3 different age groups, observed from January 2010 to January 2012. The average levels of CD3+, CD4+, CD8+, CD19+, CD16+/CD56+, CD3+/CD69+, and CD19+/CD69+ were determined for each group and compared in terms of age and sex. Results: We found significant reduction in the level of CD3+T cells related with age, but no significant changes in CD19+ B cell levels (p<0.005). Aging significantly reduces activated B cell (CD19+/CD69+) levels in males (p<0.005). Conclusions: Our results show that there may be differences between males and females in terms of immune senescence.eninfo:eu-repo/semantics/openAccessAgingLymphocytesLymphocyte SubsetsArticle20N/AQ1939625033372WOS:000218477300013