Celik, Muhammet MuratBuyukkaya, EyupUstun, NilgulNacar, Alper BugraKurt, MustafaKarakas, Mehmet FatihAkcay, Adnan Burak2025-05-102025-05-1020150043-53251613-767110.1007/s00508-015-0714-xhttps://doi.org/10.1007/s00508-015-0714-xhttps://hdl.handle.net/20.500.14720/7853Familial Mediterranean fever (FMF) may pose a risk for cardiovascular diseases due to continuous inflammatory status observed during the course of the disease. Recently, the presence of fragmented QRS (fQRS) has been recognized as a predictor of myocardial fibrosis. In this study, we aim to investigate the frequency of fQRS and its relation to Doppler-based indices. This study consisted of 80 FMF patients and 30 healthy control subjects. fQRS pattern was defined as the presence of additional R waves or RSR', evidenced by notched R or S wave on electrocardiography (ECG). The patient and the control groups underwent conventional echocardiography and tissue Doppler echocardiography. There was no significant difference between groups regarding age (29 +/- 12 vs 29 +/- 15). FMF patients exhibited a statistically higher frequency of fQRS (% 56 vs % 13) (p < 0.01). E/Em ratio showed a statistically significant increase in the FMF group with fQRS (p < 0.0001), while the mean Em value was markedly lower (p < 0.0001). FMF patients displayed a statistically significant increase in frequency of fQRS. Doppler-derived diastolic index was statistically significantly impaired in FMF patients with fQRS as compared with the patients without fQRS. In conclusion, fQRS might be a new noninvasive marker for cardiac involvement in FMF patients.eninfo:eu-repo/semantics/closedAccessFragmented QrsFamilial Mediterranean FeverTissue Doppler EchocardiographyArticle1275-6Q3Q118519025787212WOS:000352865700002