Aslanoglu, Furgan2025-05-102025-05-1020240022-152X1943-519310.1002/jhet.48602-s2.0-85196401441https://doi.org/10.1002/jhet.4860https://hdl.handle.net/20.500.14720/10843Aslanoglu, Furgan/0000-0002-5740-1716A new and efficient method for synthesizing 1,3-oxazepines has been developed. The synthetic strategy of this method is based initially on the Knoevenagel reaction to form 5-benzylidine Meldrum's acid, followed by a 7-endo-cyclization reaction with TosMIC (p-toluenesulfonylmethyl isocyanide) in the presence of base. In the optimization studies carried out on this tandem reaction, the highest yield was obtained when K2CO3 was used as the base.eninfo:eu-repo/semantics/closedAccessArticle618Q2Q213641368WOS:001251924100001