Gonullu, EdipSilav, GokalpKaya, MiktatArslan, MehmetGonullu, HayriyeArslan, HarunDemir, Halit2025-05-102025-05-1020121302-16642-s2.0-84872258910https://hdl.handle.net/20.500.14720/16784Cebi, Aysegul/0000-0003-3804-7966Aim: We aimed to determine the relationship both paraoxonase and prolidase activitys in the patients with malignant glioma. Methods: In this study, serum paraoxonase and prolidase activitys were measured on 25 healthy human and 25 patients with malignant glioma. Paraoxonase activity was measured using diethyl-p-nitrophenylphosphate as substrate, as previously described. The prolidase activity was used for measurement of proline by the method proposed by Myara et al., which is a modification of Chinard's method (Myara et al., 1982). Results: The paraoxonase and prolidase activitys were significantly lower in serum of patients with malignant glioma as a whole compared to controls. Conclusions: In the current study, the activity paraoxonase and prolidase decreased in the patients with malignant glioma. As a result the paraoxonase and prolidase decreased seems to play a major role in the pathophysiology of malignant glioma. This is the first report on serum paraoxonase and prolidase decreased activities in patients with malignant gliomas.eninfo:eu-repo/semantics/closedAccessMalignant GliomaParaoxonase ActivityProlidase ActivityArticle294N/AN/A778782WOS:000312600000012