Aklbas, EsvetAslanoglu, Furgan2025-05-102025-05-1020081042-65071563-532510.1080/104265007015570212-s2.0-43249117434https://doi.org/10.1080/10426500701557021https://hdl.handle.net/20.500.14720/6680Aslanoglu, Furgan/0000-0002-5740-1716The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (la) and 5-benzoyl-4-(2-chlorophenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (1b) were synthesized using the Biginelli three-component cyclocondensation reaction of a beta-diketone, arylaldehyde, and thiourea under microwave irradiation. Thiazolopyrimidine (2), (3) and pyrimido[2,3-b]thiazine (4) derivatives were obtained by a Simple one-pot condensation reaction of starting compound 1b and 2-bromopropionic acid, bromoacetic acid and 3-bromopropionic acid, respectively. These reactions performed under microwave irradiation and conventional conditions. That study is suggested a simple anal efficient route for the preparation of 1,2,3,4-tetrahydro-2-thioxopyrimidine and derivatives.eninfo:eu-repo/semantics/closedAccessMicrowave-AssistedBiginelli ReactionThioxopyrimidineSynthesisCyclocondensationMulticomponent ReactionArticle1831Q4Q48289WOS:000252850600009