Horo, I.Kocabaş, F.Alankuş-Çalişkan, O.Özgökçe, F.Khan, I.A.Bedir, E.2025-05-102025-05-1020161934-578X10.1177/1934578x16011012182-s2.0-85013367880https://doi.org/10.1177/1934578x1601101218https://hdl.handle.net/20.500.14720/4956Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5'-dihydroxy-3'-methoxy-isoflavone-7-O-β-D-glucoside (1), genistin (2), sissotrin (3), 5,4'-dimethoxy-isoflavone-7-O-β-D-glucopyranoside (4), (7S,8R)-5-methoxydehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside (5), 4-O-lariciresinol-glucoside (6), 2-phenylethyl-β-D-glucopyranoside (7) and β-sitosterol-3-O-β-D-glucopyranoside (8) by spectroscopic methods including 1H- and 13C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 μM concentration.eninfo:eu-repo/semantics/openAccessAstragalus LyciusCancerChemotaxanomyCytotoxic ActivityIsoflavoneLignanArticle1112Q4Q31847185030508348WOS:000390975600018