Sakin, AbdullahOzcelik, MahsunSahin, SuleymanAydemir, OzanAldemir, Mehmet NaciIliklerden, Umit HalukKotan, Mehmet Cetin2025-05-102025-05-1020220960-74041879-332010.1016/j.suronc.2022.1018092-s2.0-85134893767https://doi.org/10.1016/j.suronc.2022.101809https://hdl.handle.net/20.500.14720/7802Sakin, Abdullah/0000-0003-2538-8569; Sahin, Suleyman/0000-0001-9769-2565; Iliklerden, Umit Haluk/0000-0003-3950-5535Introduction: In this study, we aimed to examine the relation between pre-treatment 18F-FDG PET/CT metabolic parameters [(including the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and tumor lesion glycolysis (TLG)] and treatment response and survival in locally-advanced Esophageal Squamous Cell Cancer (ESCC) treated with definitive chemoradiotherapy (dCRT). Methods: A total 76 patients with locally-advanced ESCC who received dCRT between June 2015 and December 2019 were included in this retrospective study. Patients were divided into two groups as complete response (CR) or non-complete response (Non-CR) according to response to treatment. AUC was obtained as 0.749 (p < 0.001) in the ROC curve drawn by MTV for the CR. The MTV value was <= 12 cm(3), with 72.1% sensitivity and 73.0% specificity. Results: Of the 76 patients, 38 (50%) were male and 38 (50%) were female. The median age was 62 (39-84) years. The treatment response in 35 (46%) patients was CR. MTV value was > 12cm3 in 41(54%) patients. Median follow-up time was 14.5 months. In patients with MTV > 12cm3, median progression-free survival(mPFS) and median overall survival(mOS) were 9 months and 11 months, respectively, whereas mPFS and OS could not be reached in those with MTV & LE;12 cm3 (p < 0.001 and p < 0.001, respectively). In patients with non-CR, mPFS and mOS were 8 months and 9 months, respectively, whereas mPFS and OS could not be reached in patients with CR (p < 0.001 and p < 0.001, respectively). In multivariate analysis, age (odds ratio [OR], 1.07), ECOG PS (OR, 11.1), and MTV (OR, 4.73) were found to be the factors affecting treatment response. Conclusion: In our study, treatment response and MTV were found to be the factors associated with survival in patients treated with dCRT, showing the pre-treatment MTV value as a predictor of treatment response.eninfo:eu-repo/semantics/closedAccessMetabolic Tumor VolumeTumor Lesion GlycolysisEsophageal CancerChemoradiotherapySquamous Cell CarcinomaArticle43Q2Q235809492WOS:000828401900003