Ertugrul, Abdullah SeckinTekin, YasinTalmac, Ahmet Cemil2025-05-102025-05-1020171476-41721476-418010.1080/14764172.2017.1334923https://doi.org/10.1080/14764172.2017.1334923https://hdl.handle.net/20.500.14720/12092Ertugrul, Abdullah Seckin/0000-0002-9973-3161Background: The aim of this study is to determine the suitability of the Er,Cr:YSGG and 940 +/- 15-nm diode laser for the treatment of generalized aggressive periodontitis and chronic periodontitis by measuring the levels of human -defensin-1 and IL-1. Patients and Methods: A total of 26 patients were included in this study. The study was designed as a split-mouth experiment. We performed scaling and root planing in the right maxillary quadrant, scaling and root planning + Er,Cr:YSGG laser in the left maxillary quadrant, scaling and root planning + 940 +/- 15-nm diode laser in the left mandibular quadrant, and only scaling and root planing in the right mandibular quadrant. The presence of human -defensin-1 and IL-1 was analyzed with an ELISA. Results: When the baseline and post-treatment human -defensin-1 levels and IL-1 levels of the study groups were evaluated, a decrease in human -defensin-1 and IL-1 were observed in the quadrant where the Er,Cr:YSGG laser was applied in both the generalized aggressive periodontitis group and the chronic periodontitis group. Conclusions: The use of the Er,Cr:YSGG laser at non-surgical periodontal treatment decreased both IL-1 and human -defensin-1 levels. It is likely that Er,Cr:YSGG laser is more suitable for the treatment of generalized aggressive periodontitis and chronic periodontitis.eninfo:eu-repo/semantics/closedAccessDiode LaserErcr:Ysgg LaserHuman -Defensin-1Il-1Article197Q4Q240941728557642WOS:000413968900007