Ozer, Muhammet DerdaBatur, MuhammedMesen, SelmaTekin, SerekSeven, ErbilYasar, Tekin2025-05-102025-05-1020200165-57011573-263010.1007/s10792-020-01446-w2-s2.0-85085869335https://doi.org/10.1007/s10792-020-01446-whttps://hdl.handle.net/20.500.14720/6007Seven, Erbil/0000-0001-5629-291X; Ozer, Muhammet Derda/0000-0002-3954-270XPurpose To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged <= 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (<= 14 years and 15-18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 +/- 1.8 (10-18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (<= 14 years of age), and 21 (51%) were in group 2 (15-18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit (p < 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 (Z = - 2.44, p = 0.014). Conclusion Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. Instead of evaluating pediatric patients as a whole, closer follow-up and early treatment may be useful in younger age groups (<= 14 years).eninfo:eu-repo/semantics/closedAccessKeratoconusAccelerated Corneal Cross-LinkingOrbscanKeratometryPediatric AgeArticle4010Q4Q22651265832488590WOS:000537367800003