Besiroglu, L.Sozen, M.Ozbebit, O.Avcu, S.Selvi, Y.Bora, A.Bulut, M. D.2025-05-102025-05-1020110001-690X1600-044710.1111/j.1600-0447.2011.01726.x2-s2.0-79960198245https://doi.org/10.1111/j.1600-0447.2011.01726.xhttps://hdl.handle.net/20.500.14720/11605Selvi, Yavuz/0000-0003-0218-6796Objective: To investigate the regional metabolite abnormalities and changes after treatment in patients with OCD with autogenous and reactive obsessions. Method: We assessed right anterior cingulate cortex (ACC) and amygdala-hippocampal region (Am + Hpp) N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr) concentrations and NAA/Cr and Cho/Cr ratios using single-voxel proton magnetic resonance spectroscopy in 15 patients with autogenous obsessions (OCD-A), 15 patients with reactive obsessions (OCD-R) and 15 healthy controls (HC). Measurements were repeated after 16 weeks of fluoxetine treatment. Results: Baseline ACC NAA/Cr ratios of both OCD groups were significantly lower than HC. OCD-A group had significantly lower baseline NAA/Cr ratios in the Am + Hpp than other groups. These differences were more likely to be explained by higher Cr levels in ACC. We found no significant differences and changes for Cho levels and Cho/Cr ratios between groups and within groups. Significant increase in NAA/Cr ratios of OCD-A group found in the Am + Hpp was more likely to be explained by increased NAA levels. No significant changes were found in ACC NAA/Cr ratios. Conclusion: While disturbed energy metabolism in ACC might reflect a common pathology in patients with OCD regardless of symptom dimension, alterations in mesiotemporal lobe are more likely for autogenous obsessions.eninfo:eu-repo/semantics/closedAccessObsessive-Compulsive DisorderSubtypesMagnetic Resonance SpectroscopySerotonin Specific Reuptake InhibitorsLimbic SystemArticle1242Q1Q114115121627621WOS:000292606700005