Bahadir, OzlemCitoglu, Gulcin SaltanOzbek, HanefiDall'Acqua, StefanoHosek, JanSmejkal, Karel2025-05-102025-05-1020110367-326X1873-697110.1016/j.fitote.2010.12.0072-s2.0-79951680772https://doi.org/10.1016/j.fitote.2010.12.007https://hdl.handle.net/20.500.14720/1915Smejkal, Karel/0000-0002-4336-7924; Saltan, Hayriye Gulcin/0000-0001-6633-0713; Hosek, Jan/0000-0003-0975-1671Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl4-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (c) 2011 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccess(+)-Columbianadin(-)-DeltoinFuranocoumarinHepatoprotective ActivityTnf-AlphaZosimaArticle823Q2Q245445921185922WOS:000288354700025