Ciftci, HakanArpa, Muhammet DavutGulacar, Ismail MusabOzcan, LeventErsoy, Bahri2025-05-102025-05-1020201387-18111873-309310.1016/j.micromeso.2020.1102532-s2.0-85083657526https://doi.org/10.1016/j.micromeso.2020.110253https://hdl.handle.net/20.500.14720/7156Ozcan, Levent/0000-0003-4504-4237; Ersoy, Bahri/0000-0002-0075-9039; Ciftci, Hakan/0000-0001-7910-7350; Arpa, Muhammet Davut/0000-0001-9290-2404Porous magnetic nanomaterials have attracted great attention in a variety of applications, particularly in the magnetically targeted and/or controlled release of various species. In this study, a new route was determined to prepare magnetic and mesoporous montmorillonite/magnetite nanocomposites (Mt-Mag NCs). The changes of textural properties of Mt-Mag NCs as a function of the surfactant and silica precursor composition ratios were investigated for the first time. The NCs were then investigated for loading and release performance of 5-Fluorouracil (5-Fu). The NCs, selected for 5-Fu loading and release studies, showed a high surface area about 340.8 m(2)/ g, an average pore diameter of 8.24 nm, and a magnetization saturation of 18.7 emu/g. Interesting new information was also obtained in the method of determining 5-Fu by UV and the method was slightly modified according to obtained results. In vitro release experiments revealed that the NCs showed sustained release profiles of 5-Fu lasting approximately 8 h. Release profiles of 5-Fu from NCs could be fitted by Korsmeyer-Peppas and Hixson kinetics. In vitro cytotoxic study using MCF7 and CRL-4010 cell lines showed that the NCs are good candidates to delivery 5-Fu.eninfo:eu-repo/semantics/closedAccessMagnetic Mesoporous NanocompositeSilica Pillared Clay5-FluorouracilControlled ReleaseCell-CultureArticle303Q1Q1WOS:000535938200014