Yavuz, Goknur OzaydinYilgor, AbdullahYavuz, Ibrahim HalitMilanhogluz, AyselCilingir, VedatCagac, AydinBilgili, Serap Gunes2025-05-102025-05-1020191642-395X10.5114/ada.2018.748342-s2.0-85066093100https://doi.org/10.5114/ada.2018.74834https://hdl.handle.net/20.500.14720/15867Cilingir, Vedat/0000-0003-4635-2880; Yavuz, Ibrahim Halil/0000-0003-0819-2871Introduction: Peripheral neuropathy (PN) is a common neurological condition causing symmetrical and diffuse damage in nerves. The etiology of PN includes systemic diseases, toxic exposure, medications, infections, and hereditary diseases. Omalizumab is a humanized monoclonal anti-IgE antibody that exerts its activity by binding to free IgE in circulation. Aim: To investigate the relationship between omalizumab and peripheral neuropathy. Material and methods: The study included 30 patients who underwent omalizumab therapy (Xolair) due to the diagnosis of chronic urticaria. A detailed neurological and physical examination was performed in each patient both before and 3 months after the therapy. Electrophysiological examination was also performed using a Medelec Synergy instrument. Results: The 30 patients included 8 (26.7%) men and 22 (73.3%) women with a mean age of 37.5 +/- 14.14 years. No serious side effect of the medication was detected in any patient although local wound irritation occurred in 3 (10%) patients. Moreover, no change occurred in the pre-treatment Neuropathy Symptom Score (NSS) or Neurological Disability Score (NDS) of the patients and no pathological values that could result in neuropathy were observed during motor/sensory nerve conduction. However, significant changes were detected in the sensory and motor components of the nerves with regards to pre- and post-treatment values. Conclusions: Omalizumab therapy caused no peripheral neuropathy in any of our patients but altered the latency, amplitude, and velocity values of the peripheral nerves.eninfo:eu-repo/semantics/openAccessChronic UrticariaOmalizumabNeuropathyArticle362Q4Q321121631320856WOS:000467799900013