Dulger, HalukDonder, AhmetSekeroglu, Mehmet RamazanErkoc, RehaOzbay, Bulent2025-05-102025-05-1020110886-022X10.3109/0886022X.2011.5779222-s2.0-79956290611https://doi.org/10.3109/0886022X.2011.577922https://hdl.handle.net/20.500.14720/1741Reha, Erkoc/0009-0001-7230-8843; Dundar, Ahmet/0000-0003-0527-189XObjective: We have investigated the effects of active and passive smoking on renal functions in terms of glomerular filtration rate, microalbuminuria, and beta-2 microglobulin excretion. Design and method: The volunteers included in this study were classified into three groups as active smokers (n = 24), passive smokers (n = 20), and controls (n = 20). Blood and urine samples were collected from all groups. Serum glucose, urea, creatinine, and cotinine levels in the collected blood samples were measured. Also, microalbumin, beta-2 microglobulin, and creatinine levels were measured in the collected urine samples. Results: Serum cotinine levels were found to be higher in both passive and active smokers when compared with controls (p < 0.01), whereas urinary microalbumin and creatinine levels were significantly higher in active smokers (p < 0.01). The urinary microalbumin/creatinine ratio was significantly increased in both active and passive smokers compared with controls. Conclusion: The kidney and the glomerular functions may be affected even by passive smoking. In addition, increased microalbumin/creatinine ratio may be a sign of increased atherosclerosis risk in these persons.eninfo:eu-repo/semantics/openAccessActive SmokersPassive SmokersMicroalbuminuriaBeta-2 MicroglobulinCotinineArticle335Q2Q247547921574894WOS:000290670300002