Yilmaz, B. SeverOzbek, H.Citoglu, G. Saltan2025-05-102025-05-1020061388-02091744-511610.1080/138802006008975772-s2.0-33750847653https://doi.org/10.1080/13880200600897577https://hdl.handle.net/20.500.14720/6755Sever Yilmaz, Betul/0000-0003-2084-9514The water extract of Ballota inaequidens Hub.-Mor. & Patzak (Lamiaceae) was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that Ballota inaequidens caused dose-related inhibition in the acetic acid-induced abdominal stretching in mice. The medium effective dose (ED50) value of Ballota inaequidens was found to be 85.38 mg/kg. Ballota inaequidens showed no significant changes in the nociceptive threshold of the tail-flick test but did show an inhibition of paw edema induced by carrageenan. The ED50 value of Ballota inaequidens was found to be 99.42 mg/kg. The current study reveals that the water extract of Ballota inaequidens possesses promising antinociceptive and anti-inflammatory activities.eninfo:eu-repo/semantics/openAccessAnti-Inflammatory ActivityAntinociceptive ActivityBallota InaequidensMedian Lethal Dose (Ld50)Article448Q1Q2636641WOS:000241854400013