Dogan, MuratPeker, ErdalKirimi, ErcanSal, ErtanAkbayram, SinanErel, OzcanTuncer, Oguz2025-05-102025-05-1020110960-32711477-090310.1177/09603271114016382-s2.0-80055054305https://doi.org/10.1177/0960327111401638https://hdl.handle.net/20.500.14720/1255Akbayram, Sinan/0009-0001-0816-4144; Akbayram, Sinan/0000-0001-7410-4310; Sal, Ertan/0000-0003-2761-2675Objective: The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status. Patients: The study includes 69 full-term newborns (neonates with hyperbilirubinemia needing phototherapy [Group 1, n = 36] and neonates with kernicterus [Group 2, n = 33]) and 25 age-matched healthy newborn. Results: Plasma total antioxidant capacity (TAC) and serum total oxidant status (TOS) were significantly higher in Groups 1 and 2 than the control group. There was a significant difference between Group 1 and control cases for malondialdehyde (MDA; p < 0.001). Total free sulfhydryl group (TTHI) values were significantly elevated in Group 1 compared to Group 2 and control cases. Correlation analysis showed that the correlation between total bilirubin (TB) and TAC, TOS, MDA and oxidative stress index may be expressed by a quadratic curve. After phototherapy, a statistically significant increase in nitrite level was observed. Conclusion: We demonstrated that the relationship between serum TB and antioxidants and oxidative stress could be expressed by a quadratic correlation curve.eninfo:eu-repo/semantics/closedAccessNeonatal HyperbilirubinemiaKernicterusLight TherapyAntioxidantsArticle3011Q3Q21751176021393350WOS:000296157700002