Atay, Ahmet EnginSakar, Mehmet NafiCulcu, Nurdagul Serife NuraniSimsek, HakkiAkbas, HalitAcar, MuratTuzcu, Alpaslan Kemal2025-05-102025-05-1020130393-63842283-97202-s2.0-84896700396https://hdl.handle.net/20.500.14720/16916Material and methods: Sixty five patients with GDM and 66 healthy pregnants were enrolled. Paraoxonase activity, insulin levels, HOMA-IR, demographic features and anthropometric measurements were evaluated. Results: The mean paraoxonase activity was significantly diminished in patients with GDM (p:0,004). Insulin level and HOMA-IR were significantly higher in GDM patients (p:0,004 and p:0,001; respectively). The mean interval between present and previous pregnancy was significantly shorter in patients group (p:0,004). There was a significant correlation between PON1 activity and serum LDL, HDL levels and weight gained during pregnancy (p:0,001,p<0,001 and p:0,002; respectively) but not with weight and parity. However HOMA-IR was significantly correlated with weight and parity (p:0,001 and p:0,002; respectively). Discussion: Diminished PON1 activity and enhanced oxidative stress accompany to insulin resistance in the pathogenesis of GDM. Oxidative stress is associated with weight gained during first 2 trimesters of pregnancy rather than obesity.eninfo:eu-repo/semantics/closedAccessParaoxonase ActivityInsulin ResistanceGestational DiabetesArticle294Q4N/A653657WOS:000330151200008