Kuzu, BurakKostekci, SedatKarakus, FuatTuluce, Yasin2025-06-302025-06-3020252365-654910.1002/slct.2025020662-s2.0-105007610974https://doi.org/10.1002/slct.202502066https://hdl.handle.net/20.500.14720/25214This study reports the synthesis, characterization, and biological evaluation of 19 benzoxazole/benzothiazole hybrids (19a-s). The compounds were synthesized through a multi-step process and structurally confirmed via NMR, elemental, and MS analyzes. Their antiproliferative effects were assessed on MCF-7 breast cancer and HME1 healthy epithelial cells. MTT assays identified 15 compounds with significant cytotoxic activity, among which 19e, 19g, 19i, 19j, and 19k exhibited high selectivity for MCF-7 cells. ELISA results demonstrated that 19g, 19i, 19j, and 19k significantly reduced AURKA protein levels in MCF-7 cells, while sparing healthy cells, suggesting their role in inhibiting cancer cell proliferation. These findings highlight 19g, 19i, 19j, and 19k as promising selective AURKA-targeted agents for breast cancer therapy.eninfo:eu-repo/semantics/closedAccessAntiproliferationAurkaBenzothiazoleBenzoxazolePyrrolopyrazineDesign, Synthesis, and Evaluation of Pyrrolopyrazine-Substituted Benzoxazole/Benzothiazole Derivatives Targeting Aurora Kinase a in Mcf-7 CellsArticle1022Q3Q3WOS:001503239100001