Ayengin, KemalAlp, Hamit HakanHuyut, ZubeyirYildirim, SerkanAltindag, FikretAvci, Veli2025-05-102025-05-1020210303-45691439-027210.1111/and.138392-s2.0-85097956619https://doi.org/10.1111/and.13839https://hdl.handle.net/20.500.14720/6983Yildirim, Serkan/0000-0003-2457-3367; Ayengin, Kemal/0000-0002-1633-3200; Avci, Veli/0000-0003-2856-3449; Alp, Hamit Hakan/0000-0002-9202-4944We aimed to study the effect of coenzyme Q10 on pro-inflammatory cytokine, matrix metalloproteinase, oxidative DNA damage, caspase 3 and caspase 8 in ischaemia/reperfusion injury led to by testicular torsion/detorsion. Our research is a controlled experimental animal research using rats. This study was conducted with fifty-six adult male Albino Wistar rats. Interleucine-1 beta, 2, 6, 10, tumour necrosis factor-alpha, matrix metalloproteinase-2, 3, 9, 13, tissue inhibitor matrix metalloproteinase-1, 2, malondialdehyde and leucocyte 8-hydroxy-2-deoxy guanosine/10(6) deoxyguanosine was detected in serum and tissue samples. In addition, immunohistochemical analysis of caspase 2 and caspase 8 was performed. In testicular I/R injury, especially 24 hr after detorsion, oxidative damage pro-inflammatory cytokines and matrix metalloproteinases were increased. At the coenzyme Q10 group, a meaningful decrease was observed in these parameters. In addition, a decrease in the expression of caspase3 and caspase 8 was viewed in coenzyme Q10-treated groups. The coenzyme Q10 has beneficial effects on oxidative damage, pro-inflammatory cytokine levels, remodelling of extracellular matrix and apoptosis in testicular I/R injury.eninfo:eu-repo/semantics/openAccessCoq10Dna DamageIschaemiaMatrix MetalloproteinasesTestisArticle532Q2Q233368479WOS:000601126500001