Kaba, MehmetPirincci, NecipBenli, ErdalGecit, IlhanGunes, MustafaYuksel, Mehmet BilgehanKemik, Ahu Sarbay2025-05-102025-05-1020141513-736810.7314/APJCP.2014.15.1.3812-s2.0-84894059939https://doi.org/10.7314/APJCP.2014.15.1.381https://hdl.handle.net/20.500.14720/10629Gunes, Mustafa/0000-0003-2044-9086; Yuksel, Mehmet Bilgehan/0000-0002-5968-7981Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.eninfo:eu-repo/semantics/openAccessBladder CancerDkk-1Clinic-Pathological FeaturesPrognosisTurkeyArticle151N/AQ338138424528060WOS:000332001000064