Pinar, Pinar TalayYardim, YavuzSenturk, Zuhre2025-05-102025-05-1020200925-96351879-006210.1016/j.diamond.2019.1076492-s2.0-85076247565https://doi.org/10.1016/j.diamond.2019.107649https://hdl.handle.net/20.500.14720/13942Yardim, Yavuz/0000-0002-9587-096X; Senturk, Zuhre/0000-0002-0356-9345In this study, the individual and simultaneous determination of lidocaine (LID) and epinephrine (EP) were examined using an anodically pretreated boron-doped diamond (APT-BDD) electrode. The results of cyclic voltammograms of the binary mixtures of EP and LID were manifested by two irreversible and diffusion-controlled peaks at about +0.91 V (for EP) and +1.67 V (for LID) in Britton-Robinson buffer at pH 2.0. The dependence of oxidation peak potential and current on experimental and instrumental parameters was also investigated at the surface of the APT-BDD electrode. Under the optimal conditions, employing square-wave voltammetric mode, the APT-BDD electrode was used for determination of LID and EP simultaneously in the ranges of 0.1-20.0 mu mol L-1 and 1.0-100.0 mu mol L-1, with detection limits of 0.03 mu mol L-1 and 0.27 mu mol L-1, respectively. The proposed approach could be used for their determination individually and selectively (in the case of EP) in pharmaceutical dosage forms with acceptable recoveries.eninfo:eu-repo/semantics/closedAccessLidocaincEpinephrineDeterminationBoron-Doped Diamond ElectrodePharmaceutical Dosage FormsArticle101Q2Q2WOS:000510954000042