Cetin, Yaser SaidDuzenli, UfukBerkoz, MehmetOzkan, HuseyinBozan, Nazim2025-05-102025-05-1020202149-71092149-649810.32448/entupdates.744725https://doi.org/10.32448/entupdates.744725https://hdl.handle.net/20.500.14720/7142Objective: 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F-2(alpha) (8-iso-PGF(2)(alpha)) are indicators of oxidative stress in the human body. The aim of the present study was to investigate serum 8-OHdG and 8-iso-PGF(2)(alpha) levels in patients with larynx carcinoma and to compare them with healthy controls. Methods: A total of 50 patients, consisting of 25 patients with larynx carcinoma (study group) and 25 healthy subjects (control group), were enrolled in the present study. Serum 8-OHdG concentration was measured using an ELI-SA kit, whereas an enzyme immunoassay kit was utilized for the measurement of serum 8-iso-PGF(2)(alpha) levels. TNM stages of the patients were recorded from the patient records in the study group. Results: 8-OHdG and 8-iso-(2)(alpha) levels were significantly higher in patients with larynx carcinoma than the control subjects. 8-OHdG levels were significantly higher in patients with LN metastases than the patients without LN metastases in the study group. Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF(2)(alpha) levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.eninfo:eu-repo/semantics/openAccessLarynx CancerOxidative Stress8-Hydroxy-2&AmpProstaglandin F2 AlphaPrime-DeoxyguanosineArticle102N/AN/A335339385088WOS:000605958300006