Begenik, H.Kemik, A. S.Emre, H.Dulger, A. C.Demirkiran, I.Ebinc, S.Kemik, O.2025-05-102025-05-1020140960-32711477-090310.1177/09603271135105372-s2.0-84904764387https://doi.org/10.1177/0960327113510537https://hdl.handle.net/20.500.14720/15637Kemik, Ozgur/0000-0002-4612-1428Serum Dickkopf-1 (DKK-1) is elevated in many malignancies and is an important indicator of malignant potential. However, its significance in esophageal squamous cell cancer (ESCC) has not yet been clarified. We hypothesized a role for DKK-1 in patients with ESCC. The study consisted of 90 ESCC patients and 85 healthy controls. After diagnosis, the level of DKK-1 was measured in the serum samples by enzyme-linked immunosorbent assay and the levels of DKK-1 were much higher in the ESCC patients than in the healthy control group (p < 0.0001). For serum DKK-1, the sensitivity and specificity of the assay were 70 and 80%, respectively. The preoperative serum DKK-1 level was elevated in the ESCC patients. Although serum DKK-1 is not a specific biomarker for ESCC, it might be a useful marker for the diagnosis and treatment of ESCC.eninfo:eu-repo/semantics/openAccessEsophageal Squamous Cell CancerDickkopf-1Article338Q3Q278578824220876WOS:000339694900001