Aslanoglu, FurganYazici, Ahmet2025-05-102025-05-1020230039-79111532-243210.1080/00397911.2023.22455062-s2.0-85167513880https://doi.org/10.1080/00397911.2023.2245506https://hdl.handle.net/20.500.14720/9684Aslanoglu, Furgan/0000-0002-5740-1716Thiouracil and uracil derivatives are among the bioactive molecules used in the treatment of many diseases, such as 6-propylthiouracil and 5-fluorouracil. A new synthesis method of 6-methylthiouracil and 6-methyluracil was developed in this study. Various 6-methylthiouracil and 6-methyluracil derivatives were obtained by reacting 2,2,6-trimethyl-4H-1,3-dioxin-4-one with thiourea and urea compounds in the presence of Yb(TFA)(3) according to this new method. Optimization of this new method was performed. The structures of 6-methylthiouracil and 6-methyluracil derivatives were characterized.eninfo:eu-repo/semantics/closedAccess26-Trimethyl-4H-13-Dioxin-4-One6-Methylthiouracil6-MethyluracilYb(Tfa)(3)>6-Methylthiouracil and 6-Methyluracil Derivatives Synthesized by Reaction of Acetylketene With Thiourea and Urea Compounds in Presence of Yb(Tfa)3Article5320Q3Q217131721WOS:001044063000001