Bilgili, S. G.Calka, O.Karadag, A. S.Akdeniz, N.Kosem, M.2025-05-102025-05-1020120960-327110.1177/09603271114128042-s2.0-84858638008https://doi.org/10.1177/0960327111412804https://hdl.handle.net/20.500.14720/1191Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.eninfo:eu-repo/semantics/closedAccessFixed Drug EruptionGeneralizedNaproxenNonsteroidal Anti-Inflammatory DrugDiclofenacArticle312Q3Q219720021677025WOS:000300818200010