Yardim, YavuzAli, Hoshyar SaadiBarzani, Hemn A. H.2025-05-102025-05-1020220925-96351879-006210.1016/j.diamond.2022.1088712-s2.0-85124233723https://doi.org/10.1016/j.diamond.2022.108871https://hdl.handle.net/20.500.14720/14390Yardim, Yavuz/0000-0002-9587-096X; Ali, Hoshyar/0000-0002-9138-485X; Barzani, Hemn Abdulazeez Hakeem/0000-0002-1875-7760The current study offers an electroanalytical investigation and a novel voltammetric approach for the quanti-tative analysis of famciclovir (FCV) utilizing an unmodified boron-doped diamond (BDD) electrode. An irre-versible, well-defined, diffusion-controlled anodic peak was observed at approximately +1.27 V (vs. Ag/AgCl) in acetate buffer solution (ABS, 0.1 mol L-1, pH 4.7) when the agent was tested using cyclic voltammetry. The voltammetric signals of the oxidation peaks are pH dependent (ranging from 2.0 to 7.0). Using square-wave mode, a good linear response was obtained for FCV quantification in 0.1 mol L-1 ABS (pH 4.7) solution at +1.26 V (vs. Ag/AgCl). Wide dynamic range was found for 0.1 to 50.0 mu g mL-1 (3.11 x 10-( 7)-1.56 x 10(-4) mol L-1), with a low detection limit of 0.029 mu g mL-1 (9.02 x 10(-8) mol L-1). Applicability of the proposed method for the determination of FCV was demonstrated in the pharmaceutical formulation and model serum samples.eninfo:eu-repo/semantics/closedAccessElectrochemical DeterminationSquare-Wave VoltammetryPretreatmentDrug AnalysisArticle123Q2Q2WOS:000787889900001