Yardim, YavuzAli, Hoshyar SaadiSulaiman, Seerwan HamadameenBarzani, Hemn A. H.2026-04-022026-04-0220262522-57662522-575810.1007/s42250-026-01653-5https://hdl.handle.net/123456789/30036https://doi.org/10.1007/s42250-026-01653-5The purpose of this research is to explain the voltammetric evaluation of aprepitant (APT) using the boron-doped diamond (BDD) electrode with an anionic surfactant media. The APT was measured by cyclic voltammetry in a 0.1 mol L- 1 H2SO4 solution, revealing adsorption and diffusion-controlled processes. The oxidation peaks were well-defined at + 1.5 V (vs. Ag/AgCl). The addition of sodium dodecyl sulfate (an anionic surfactant) in the selected supporting electrolyte significantly increased the oxidation peak currents of APT. To determine APT in a 0.1 mol L- 1 H2SO4 solution, a linear relationship was observed under the optimized experimental conditions, including 1.0 & times; 10(- 4) mol L- 1 SDS at an accumulation potential of + 1.5 V (vs. Ag/AgCl) for 30 s under open-circuit conditions. The linear concentration was discovered by applying 1.0 to 25.0 & micro;g mL(- 1) (1.87 & times; 10(- 6) - 4.68 & times; 10(- 5) mol L- 1) as well as the detection limit 0.19 & micro;g mL(- 1) (3.56 & times; 10(- 7) mol L- 1). The established technology was successfully utilized to measure APT in pharmaceutical formulations and urine samples. Our research indicates that this is the first non-modified electroanalytical method for voltammetric APT detection to be identified.eninfo:eu-repo/semantics/closedAccessBoron-Doped Diamond ElectrodeAnionic SurfactantAprepitantReal SamplesVoltammetric AnalysisArticle