Subak, HasretPinar, Pinar Talay2025-05-102025-05-1020242576-642210.1021/acsabm.4c001862-s2.0-85189774475https://doi.org/10.1021/acsabm.4c00186https://hdl.handle.net/20.500.14720/10986Ruxolitinib (RXL) is a Janus kinase inhibitor used for treating intermediate- or high-risk myelofibrosis. This study presents an electrode modified with electrochemically polymerized taurine on a carbon paste electrode via cyclic voltammetry (CV). The surface characterization of the poly(taurine)-CP electrode was evaluated by using electrochemical (electrochemical impedance spectroscopy-EIS, CV), morphological (scanning electron microscope-SEM), and spectroscopic (Fourier-transform infrared spectroscopy-FT-IR) techniques. Under optimized conditions, RXL exhibited good linearity within the 0.01-1.0 mu M concentration range, with a limit of detection (LOD) of 0.005 mu M. The proposed electrochemical sensor demonstrated excellent selectivity, accuracy, precision, and repeatability. Furthermore, it effectively detected RXL in human urine and pharmaceutical samples.eninfo:eu-repo/semantics/openAccessJanus Kinase InhibitorRuxolitinibElectrochemicaloxidationTaurineElectropolymerizationArticle75N/AQ13179318938581305WOS:001200609200001