Kurdoglu, MertihanKurdoglu, ZehraOzen, SuleymanKucukaydin, ZehraBulut, GulayErten, RemziKamaci, Mansur2025-05-102025-05-1020110300-55771619-399710.1515/JPM.2011.0242-s2.0-79960220109https://doi.org/10.1515/JPM.2011.024https://hdl.handle.net/20.500.14720/11593Kurdoglu, Mertihan/0000-0002-5344-9739; Erten, Remzi/0000-0001-7775-5792; Kucukaydin, Zehra/0000-0001-5908-2408; Kurdoglu, Zehra/0000-0001-5191-1072Objectives: To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity. Study design: Third trimester placental samples obtained from deliveries of preeclamptic (n = 34) and normotensive healthy pregnant women (n = 35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n = 14) and severe (n = 20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity. Results: When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05). Conclusions: Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.eninfo:eu-repo/semantics/closedAccessImmunohistochemistryLaminin Receptor 1PlacentaPreeclampsiaConference Object394Q2Q241141621391874WOS:000292642200009