Tasdemir, VolkanKuzu, BurakTan, MeltemGenc, HasanMenges, Nurettin2025-05-102025-05-1020190936-52141437-209610.1055/s-0037-16108592-s2.0-85061136091https://doi.org/10.1055/s-0037-1610859https://hdl.handle.net/20.500.14720/13646Menges, Nurettin/0000-0002-5990-6275N-Propargyl-2-aroylimidazoles synthesized and converted into the corresponding ketoximes. Under various conditions, several mono- and diketoxime imidazole derivatives were formed by converting the carbonyl or carbonyl and propargyl groups into oxime groups. N-Propargyl monooxime imidazole derivatives were cyclized by treatment with CuI to give various imidazopyrazine N-oxides. Several copper salts, such as CuOAc, CuSO (4) , and CuOTf, formed the same cyclization product. This cyclization reaction occurred only in the presence of Cu(I) or Cu(II) salts; other transition metals such as Au, Ag, In, and Fe did not yield cyclic products. The nucleus-independent chemical shift method was used to calculate the aromaticity of the bicyclic rings.eninfo:eu-repo/semantics/closedAccessAlkynesCyclizationCopper CatalysisImidazopyrazine OxidesOximesArticle303Q3Q3307310WOS:000458925800010