Kuzu, BurakTan, MeltemGulcin, IlhamiMenges, Nurettin2025-05-102025-05-1020210365-62331521-418410.1002/ardp.2021001882-s2.0-85107318417https://doi.org/10.1002/ardp.202100188https://hdl.handle.net/20.500.14720/10213Gulcin, Ilhami/0000-0001-5993-1668; Menges, Nurettin/0000-0002-5990-6275In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure-activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.eninfo:eu-repo/semantics/closedAccessCarbonic Anhydrase InhibitionDockingImidazole RingNon-Zinc BindingSar StudyArticle35410Q1Q134096646WOS:000658294300001