Ramazan Şekerǒlu, M.Sahin, H.Dülger, H.Algün, E.2025-05-102025-05-1020000009-912010.1016/S0009-9120(00)00190-92-s2.0-0034477316https://doi.org/10.1016/S0009-9120(00)00190-9https://hdl.handle.net/20.500.14720/6326Objectives: The aim of the present study was to investigate the effect of dietary treatment on serum and erythrocyte lipid peroxidation and erythrocyte antioxidative enzyme activity of patients with Type 2 diabetes. Design and methods: A total of 30 patients with newly diagnosed as Type 2 diabetes were enrolled to the study. A total of 30 healthy subjects served as controls. Diabetic patients were given standard dietary treatment that was composed of 50% to 55% carbohydrate and 30% fat for 2 months. No diet was applied for controls. For both groups serum and erythrocyte lipid peroxidation and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were obtained at first and at the end of 2 months. Results: Diabetic patients had higher serum and erythrocyte lipid peroxidation than those of controls before dietary treatment (p < 0.05). However, there was no absolute differences in erythrocyte SOD and GSH-Px (p > 0.05). At the end of 2 months of dietary treatment, while diabetics had still higher glucose and erythrocyte lipid peroxidation than controls (p < 0.05), serum lipid peroxidation, erythrocyte SOD, and GSH-Px levels did not differ significantly from those of controls (p > 0.05). In diabetic patients, after 2 months of dietary treatment, whereas serum and erythrocyte lipid peroxidation decreased, erythrocyte SOD and GSH-Px activities showed significant increase (p < 0.05). Conclusions: Our results showed significant alteration in serum and erythrocyte lipid peroxidation and erythrocyte antioxidant enzyme status of patients with Type 2 diabetes by dietary treatment. However, whether such alterations have clinical importance for diabetic patients needs further investigation. Copyright © 2001 The Canadian Society of Clinical Chemists.eninfo:eu-repo/semantics/closedAccessDiabetes MellitusDietary TreatmentGlutathione PeroxidaseLipid PeroxidationSuperoxide DismutaseArticle338Q2Q26696741116601511166015WOS:000166882400010