Karakus, YagmurEkin, SuatIlter, ServerEdiz, LeventEkin, Emre Can2025-05-102025-05-1020242948-24372948-244510.1007/s12018-024-09302-62-s2.0-85209212314https://doi.org/10.1007/s12018-024-09302-6https://hdl.handle.net/20.500.14720/11119Ekin, Suat/0000-0002-6502-5028In this study, osteoporosis (OS), osteopenia (OP), postmenopausal women with osteoporosis (PMOS) and osteopenia (PMOP), and control participants were evaluated for erythrocyte. CAT, GSH-Px, SOD enzyme activities, MDA, GSH, serum phylloquinone, cholecalciferol, retinol, alpha-tocopherol, TSA, TAS, Co, Mn, Fe, Zn, Cu, Se, Ni, Cd, Pb, Mg, Ca, P, K, Cl levels, and the relations of parameters (F-L-BMD, LT-FT-score) were assessed. In this study, element analyses were carried out using ICP-OES and vitamin determination using the HPLC method. Statistical analyses showed that the OS group had significantly lower FBMD (p < 0.001), LBMD (p < 0.001), GSH (p < 0.01), GSH-Px (p < 0.001), CAT (p < 0.001), alpha-tocopherol (p < 0.05), retinol (p < 0.05), cholecalciferol (p < 0.001), phylloquinone (p < 0.01), Se (p < 0.01), Fe (p < 0.05), Cu (p < 0.05), Co (p < 0.001), Zn (p < 0.001), and Mg (p < 0.01) levels than the control group. However, levels of SOD (p < 0.05) and MDA (p < 0.01) are significantly higher than the control group. It was revealed that there is a significant correlation between Mn-L BMD (r = 0.426; p = 0.024), retinol-L BMD (r = 0.502; p = 0.007), cholecalciferol-L BMD (r = - 0.520; p = 0.005), and with OP; also between retinol-L BMD (r = 0.607; p = 0.008) and with PMOS; also between K-F BMD (r = - 0.504; p = 0.009), Co-LT score (r = - 0.432; p = 0.031) and with PMOP. Our study demonstrates that lower retinol, Co, and Mn and increased OSI and K levels are significantly related to decreased L BMD and F BMD status and oxidative stress in OP, PMOS, and PMOP. A deficiency of Zn, Co, Se, cholecalciferol, and phylloquinone can be a risk factor for the progression of OS, OP, PMOS, and PMOP and could have a negative effect on bone density.eninfo:eu-repo/semantics/closedAccessOsteoporosisOsteopeniaPostmenopausal OsteoporosisTotal Sialic AcidTrace ElementVitaminArticle221N/AN/AWOS:001353586500001