Yildizhan, R.Ilhan, G.A.Yildizhan, B.Kolusari, A.Adali, E.Bugdayci, G.2025-05-102025-05-1020111556-565310.1016/j.fertnstert.2011.04.0732-s2.0-79959869560https://doi.org/10.1016/j.fertnstert.2011.04.073https://hdl.handle.net/20.500.14720/6635Objective: To evaluate retinol-binding protein 4 (RBP4), leptin, and asymmetric dimethylarginine (ADMA) levels in young women with polycystic ovary syndrome (PCOS) and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters. Design: Clinical study. Setting: University hospital. Patient(s): Fifty-seven young women with PCOS (obese [n = 27] and nonobese [n = 30]) and 27 age-matched healthy controls. Intervention(s): History and physical examination, peripheral venous blood sampling. Main Outcome Measure(s): Asymmetric dimethylarginine, RBP4, leptin, LH, FSH, DHEAS, total T, E2, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride (TG), and homeostasis model assessment insulin resistance index (HOMA-IR). Result(s): Obese women with PCOS had significantly higher HOMA-IR, DHEAS, leptin, RBP4, and ADMA levels. Leptin levels were significantly increased in nonobese subjects with PCOS. Leptin and ADMA levels were positively correlated with HOMA-IR in PCOS. There was no correlation between RBP4 and HOMA-IR. Leptin, RBP4, and ADMA levels are positively correlated in PCOS. Conclusion(s): [1] Young obese women with PCOS have increased ADMA, RBP4, and leptin levels, and they are positively correlated with each other. [2] The increased levels of leptin are independent of obesity, and leptin seems to have an association with IR. [3] Levels of RBP4 may not reflect IR in PCOS. © 2011 by American Society for Reproductive Medicine.eninfo:eu-repo/semantics/closedAccessAdmaInsulin Resistance (Homa-Ir)LeptinNonobeseObesePcosRbp4Article961Q1Q124625021600576