Gunes, MustafaKemik, Ahu SerapPirincci, NecipGecit, IlhanTaken, KeremYuksel, Mehmet BilgehanEryilmaz, Recep2025-05-102025-05-1020131513-736810.7314/APJCP.2013.14.2.8732-s2.0-84877652965https://doi.org/10.7314/APJCP.2013.14.2.873https://hdl.handle.net/20.500.14720/1480Yuksel, Mehmet Bilgehan/0000-0002-5968-7981; Gunes, Mustafa/0000-0003-2044-9086Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.eninfo:eu-repo/semantics/openAccessMmp-7Mmp-9Timp-1Bladder CancerPathological ParametersArticle142N/AQ387387623621254WOS:000324920000048