Gunes, MustafaGecit, IlhanPirincci, NecipKemik, Ahu SarbayPurisa, SevimCeylan, KadirAslan, Mehmet2025-05-102025-05-1020130171-52161432-133510.1007/s00432-012-1305-02-s2.0-84874996080https://doi.org/10.1007/s00432-012-1305-0https://hdl.handle.net/20.500.14720/1451Gunes, Mustafa/0000-0003-2044-9086Human neutrophil proteins-1, -2, and -3 (HNPs -1, -2, and -3) are expressed in several tumor types. However, the role of HNPs 1-3 in human bladder cancer has not yet been determined. We investigated the association between the plasma levels of HNPs 1-3 and clinicopathological parameters in bladder cancer patients. The plasma levels of HNPs 1-3 were measured in 60 patients with bladder cancer and in 58 healthy controls. The plasma levels of HNPs 1-3 were determined by a solid-phase enzyme-linked immunosorbent assay (ELISA). Plasma samples were obtained before surgery. Plasma samples were permitted to clot and were then stored at -80 A degrees C until use. The levels of the HNPs increased from grade 1 to 4 tumors and this difference was statistically significant (p < 0.001). Additionally, plasma HNP levels were significantly higher in patients with metastatic bladder cancer and in patients with lymphovascular involvement, metastasis of the lymph nodes, and increased tumor burden (p < 0.001). The preoperative plasma levels of HNPs 1-3 paralleled the progression and pathological stages of the malignancies. This study suggests that HNPs 1-3 promote tumor invasion and are potential indicators of disease progression in patients with bladder cancer.eninfo:eu-repo/semantics/closedAccessBladder CancerClinicopathological ParametersHuman Neutrophil Proteins-1,-2, And-3Article1392Q2Q319519923011762WOS:000313827600004