Kavak, E.Algso, M. A. S.Konus, M.Yilmaz, C.Lazoglu, A.Karaagac, S. U.Kivrak, A.2025-05-102025-05-1020211070-42801608-339310.1134/S10704280210101392-s2.0-85101779491https://doi.org/10.1134/S1070428021010139https://hdl.handle.net/20.500.14720/6933Kavak, Emrah/0000-0002-6161-2030; Konus, Metin/0000-0002-9953-1375; Yilmaz, Can/0000-0002-0028-6614; Kivrak, Arif/0000-0003-4770-26862,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.eninfo:eu-repo/semantics/closedAccessThiopheneCoupling ReactionsHeteroaromatic CompoundsAdmeAntioxidantsArticle571Q4Q49199WOS:000621823200013