Oto, GokhanEkin, SuatOzdemir, HulyaDemir, HalitYasar, SemihLevent, AbdulkadirKaki, Baris2025-05-102025-05-1020111513-73682-s2.0-79958782513https://hdl.handle.net/20.500.14720/17169Yasar, Semih/0000-0003-2754-6030; Yasar, Semih/0000-0002-2149-405X; Ekin, Suat/0000-0002-6502-5028; Ozdemir, Hulya/0000-0002-6045-8342; Levent, Abdulkadir/0000-0001-5792-419XAim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p <= 0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.eninfo:eu-repo/semantics/closedAccessAntioxidantDmbaLipid PeroxidationPlantago MajorRatArticle122N/AQ353153521545225WOS:000293172800035