Zora, MetinDemirci, DenizKivrak, ArifKelgokmen, Yilmaz2025-05-102025-05-1020160040-403910.1016/j.tetlet.2016.01.0712-s2.0-84957427854https://doi.org/10.1016/j.tetlet.2016.01.071https://hdl.handle.net/20.500.14720/14933Kivrak, Arif/0000-0003-4770-2686; Zora, Metin/0000-0001-7764-2288A facile, one-pot, general synthetic method for the preparation of 4-(phenylselanyl)pyrazoles is described. When reacted with hydrazines, alpha,beta-alkynic aldehydes produced in situ alpha,beta-alkynic hydrazones, which, upon treatment with phenylselenyl chloride, undergo cyclization to afford 4-(phenylselanyl)pyrazoles in good to high yields. This cyclization has been found to be general for a variety of in situ generated alpha,beta-alkynic hydrazones and exhibits good tolerance to a broad range of substituents, including electron-donating and electron-withdrawing groups. The enrichment of the pyrazole core with a selenyl moiety as well as with aryl and/or ferrocenyl groups may offer potential for the synthesis of molecules with pronounced or distinct biological activities. (C) 2016 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessPyrazoleSeleniumCyclizationFerroceneHydrazinePropargyl AldehydeArticle579Q3Q3993997WOS:000373408800007