Atli, M.2025-05-102025-05-1020131680-69051729-050310.4314/ahs.v13i3.62-s2.0-84883728964https://doi.org/10.4314/ahs.v13i3.6https://hdl.handle.net/20.500.14720/1479Background: It has been suggested that physical activity is an important factor in the prevention and treatment of cardiovascular diseases. Low serum paraoxononase-1 (PON1) activity is with an associated risk of atherosclerotic disease. Objectives: In this study, we aimed to investigate serum PON1 activity and lipid hydroperoxide (LOOH) levels in adult football players after three days football tournament. Methods: Twenty-three adult male football players and 23 sedentary male subjects after three days football tournament were enrolled. Serum paraoxonase, arylesterase activities and LOOH levels were determined. Results: Serum paraoxonase and arylesterase activities were signiucantly higher in football players than sedentary subjects (all, p<0.05), while LOOH levels were significantly lower (p<0.05). Serum LOOH levels were inversely correlated with paraoxonase and arylesterase activities (r=-0.552, p<0.001; r=-0.812, p<0.001; respectively) in adult football players. Conclusion: Our data show, for the first time, that physical activity is associated with increased PON1 activity and decreased oxidative stress after three days football tournament. In addition, physical activity for a healthy life is important in increasing serum PON1 activity, and this may play a role in the prevention of atherosclerosis.eninfo:eu-repo/semantics/openAccessFootball PlayersPhysical ActivityPon1 ActivityLipid HydroperoxideArticle133Q4Q256557024250290WOS:000325698500007