Solgun, Derya GungorduOzdemir, SadinDundar, AbdurrahmanAgirtas, Mehmet Salih2025-05-102025-05-1020240268-26051099-073910.1002/aoc.73242-s2.0-85177781089https://doi.org/10.1002/aoc.7324https://hdl.handle.net/20.500.14720/9628Dundar, Abdurrahman/0000-0002-7930-1054In this study, 4-(2-(4-methylthiazol-5-yl) ethoxy) phthalonitrile (3) and zinc phthalocyanine complex (4) were synthesized and characterized. UV-vis and fluorescence spectra, aggregation, and fluorescence parameters of the zinc phthalocyanine compound were investigated. As biological properties, DPPH radical capture, antidiabetic, DNA cutting, antimicrobial, photodynamic antimicrobial, anti-biofilm activities, and microbial cell viability parameters of the compounds were determined. The highest antioxidant activity was found as 62.80% at 100 mg/L concentration with compound 4, and compound 4 also showed the best antidiabetic activity as 65.17% at 400 mg/L concentration. In DNA cutting activity, it was determined that 3 and 4 cut DNA at all concentrations. For compounds 3-4, the minimum inhibitory concentration (MIC) values were found to be 32 and 16 mg/L for Enterococcus hirae and Enterococcus feacalis, respectively. The strongest MIC value of photodynamic antimicrobial activity was achieved as 4 mg/L for E. feacalis with 4. It was observed that both compounds inhibited the microbial viability activity of Escherichia coli by 100% at concentrations of 100 mg/L. Compound 4 inhibited biofilms of Pseudomonas aureginosa and Staphylococcus aureus as 92.48% and 98.56% at 50 mg/L concentration, respectively. In this study, the synthesis and characterization of the new zinc phthalocyanate complex and the investigation of many biological properties are included.imageeninfo:eu-repo/semantics/closedAccessAntimicrobialAntioxidantDna CleavagePhthalocyanineSynthesisArticle381Q1Q1WOS:001108892800001