Oto, GokhanEkin, SuatYasar, SemihOzdemir, HulyaYur, Fatmagul2025-05-102025-05-1020111684-53152-s2.0-79959336037https://hdl.handle.net/20.500.14720/17115Ekin, Suat/0000-0002-6502-5028; Yasar, Semih/0000-0002-2149-405X; Yasar, Semih/0000-0003-2754-6030; Ozdemir, Hulya/0000-0002-6045-8342This study was designed to evaluate the effect of CoQ(10) and vitamin E on serum total sialic acid (TSA), lipid bound sialic acid (LSA) and some elements in rat administered doxorubicin (DXR). Cu levels were increased in the group treated with DXR + vitamin E in comparison with DXR (p<0.05) and CoQ(10) groups (p = 0.001). Furthermore, copper levels were increased in the group treated with DXR + CoQ10 in comparison with CoQ(10) group (p < 0.05). Zn levels were decreased in the group treated with DXR + vitamin E in comparison with CoQ(10) group (p < 0.05). Mg levels were decreased in subjects treated with DXR + vitamin E in comparison with the control group values (p < 0.05). Particularly, the observed increase in Cu levels in rats from DXR + vitamin E group might be due to the decrease of vitamin E. However, the oxidative damage could be as a result of DXR occurence and may be helpful to clinicians in chemotherapy using anthracycline.eninfo:eu-repo/semantics/closedAccessDoxorubicinTotal Sialic Acid (Tsa)Lipid Bound Sialic Acid (Lsa)Trace ElementsMineralsArticle1026N/AN/A52195224WOS:000294614000019