Bartin, Mehmet KadirKemik, OzgurCaparlar, Mehmet AliBostanci, Mustafa TanerOner, Muzaffer Onder2025-05-102025-05-1020161306-696X10.5505/tjtes.2016.476502-s2.0-84986305504https://doi.org/10.5505/tjtes.2016.47650https://hdl.handle.net/20.500.14720/15267Bartin, Mehmet Kadir/0000-0003-0648-861X; Kemik, Ozgur/0000-0002-4612-1428BACKGROUND: Postoperative serum inflammatory cytokine levels are thought to reflect the magnitude of surgical stress. Cytokine interleukin-6 (IL-6) is an early marker of systemic inflammatory response and tissue damage. This study evaluated levels of IL-6 after open and laparoscopic appendectomy to compare the degree of surgical stress associated with these procedures. METHODS: IL-6 levels were measured pre- and postoperatively in the plasma of 200 consecutive patients with a diagnosis of acute appendicitis. After preoperative randomization, 100 patients underwent open appendectomy, and 100 patients underwent laparoscopic appendectomy. RESULTS: Preoperative concentrations of IL-6 were 65.22 +/- 4.76 pg/mL in the open appendectomy group and 65.73 +/- 6.34 pg/mL in the laparoscopic appendectomy group (p=0.752). Postoperative levels were 105.28 +/- 16.14 pg/mL and 76.11 +/- 16.18 pg/mL, respectively (p<0.05). CONCLUSION: Lower postoperative serum IL-6 levels suggest that laparoscopic surgery is associated with lower degree of surgical stress. Laparoscopic appendectomy has significant advantage over open appendectomy due to more rapid postoperative recovery.eninfo:eu-repo/semantics/openAccessInterleukin (Il)-6Laparoscopic AppendectomyOpen AppendectomyArticle225Q4Q346647027849323204148WOS:000386543000010