Yildiz, HanifiAlp, Hamit HakanEkin, SelamiArisoy, AhmetGunbatar, HulyaAsker, SelviHaylu, Mine2025-05-102025-05-1020212666-99272666-991910.1016/j.idnow.2021.06.3022-s2.0-85108806619https://doi.org/10.1016/j.idnow.2021.06.302https://hdl.handle.net/20.500.14720/8006Ekin, Selami/0000-0001-5922-0348; Yildiz, Hanifi/0000-0003-0735-5034; Mermit, Buket/0000-0002-4946-7029; Alp, Hamit Hakan/0000-0002-9202-4944Introduction: The SARS-CoV-2 virus affects many organs, especially the lungs, with widespread inflammation. We aimed to compare the endogenous oxidative damage markers of coenzyme Q10, nicotinamide dinucleotide oxidase 4, malondialdehyde, and ischemia-modified albumin levels in patients with pneumonia caused by SARS-CoV-2 and in an healthy control group. We also aimed to compare these parameters between patients with severe and non-severe pulmonary involvement. Methods: The study included 58 adult patients with SARS-CoV-2 pneumonia and 30 healthy volunteers. CoQ10 and MDA levels were determined by high-pressure liquid chromatography. NOX4 and IMA levels were determined by ELISA assay and colorimetric method. Results: Higher levels of CoQ10, MDA, NOX4, and IMA and lower levels of COQ10H were observed inpatients with SARS-CoV-2 pneumonia than in the control group. MDA, IMA, NOX4, and CoQ10 levels were significantly higher in patients with severe pulmonary involvement than in patients with non-severe pulmonary involvement, but no significant difference was observed in CoQ10H levels. CoQ10 levels were significantly and positively correlated with both ferritin and CRP levels. Conclusion: SARS-CoV-2 pneumonia is significantly associated with increased endogenous oxidative damage. Oxidative damage seems to be associated with pulmonary involvement severity.eninfo:eu-repo/semantics/openAccessArticle515Q3Q242943434146758WOS:000682481600005