Ak, HakanGulsen, IsmailKara, MikailAtalay, TugayAkyol, VeyselRagbetli, Murat Cetin2025-05-102025-05-1020151302-16642-s2.0-84935056268https://hdl.handle.net/20.500.14720/3909Ragbetli, Murat Cetin/0000-0002-8189-264X; Akyol, Veysel/0000-0002-6355-441XAim: This study evaluated the therapeutic efficacy of resveratrol (RVT), a naturally occurring polyphenol, during the management of acute nerve injury in a rat model. Materials and Methods: A total of 28 rats were divided into trauma, control and low-and high-dose RVT groups (all n = 7). In all three non-control groups, trauma was induced by a medium-pressure aneurysm clip, applied to the sciatic nerve for 30 s. After trauma, the animals were treated with RVT for 7 days, after which nerve tissue samples were obtained from the site of injury for use in histological and stereological analyses. Results: There was a significant group difference in myelin thickness. At 50 mg/kg, RVT treatment was associated with increased myelin thickness, but a decrease was observed at 100 mg/kg. Conclusion: RVT has a beneficial effect on acute crush injury of the sciatic nerve at a dose of 50 mg/kg.eninfo:eu-repo/semantics/closedAccessSciatic NerveResveratrolMyelin ThicknessAxon DiameterArticle322N/AN/A303310WOS:000361529400003