Kaba, S.Karaman, K.Komuroglu, U.Bala, K. A.Demir, N.Kocaman, S.Ceylan, N.2025-05-102025-05-1020151128-36022-s2.0-84966377250https://hdl.handle.net/20.500.14720/4702Ceylan, Nesrin/0000-0001-5844-1261; Demir, Nihat/0000-0003-3287-7221; Bala, Keziban Asli/0000-0001-8755-7714OBJECTIVE: To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition. PATIENTS AND METHODS: We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age-and sex-matched controls were also included in the study. Fasting serum nesfatin-1 concentrations were measured by using Enzyme-Linked Immunosorbent Assay (ELISA) technique. RESULTS: Mean nesfatin-1 level was significantly higher in underweight children when compared to controls (p < 0.001). There was no correlation between serum nesfatin-1 levels and anthropometrics markers. CONCLUSIONS: Our results suggest that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children.eninfo:eu-repo/semantics/closedAccessNesfatin-1Loss Of AppetiteChildhoodArticle1924Q2Q24703470626744860WOS:000369542600009