Algul, S.Ozcelik, O.Oto, G.Sarikaya, M.Goceroglu, R. T.Embiyaoglu, N. M.Akcan, A. G.2025-05-102025-05-1020211128-360210.26355/eurrev_202102_248722-s2.0-85101154182https://doi.org/10.26355/eurrev_202102_24872https://hdl.handle.net/20.500.14720/6930Embiyaoglu, Nuri Mert/0000-0002-1627-8539OBJECTIVE: We evaluated the efficacy of curcumin administration on blood glucose levels and its relationship with nesfatin-1 levels in blood brain and adipose tissue of streptozotocin-induced diabetic rats. MATERIALS AND METHODS: A total of 28 male rats were divided into four groups: control group, type 2 diabetes mellitus (DM) group, control plus curcumin group and type 2DM plus curcumin group. After fifteen days, blood samples were collected from sacrificed rats. Nesftain-1 levels were analysed from blood, brain, and fat tissues of rats in all groups. RESULTS: Nesfatin-1 level was found to be significantly lower in blood, brain and fat tissues of type 2 DM rats compared to the control group. A significant decrease in fasting blood glucose levels was observed in the curcumin administration group compared to type 2 DM group. Improvement of fasting blood glucose level was accompanied by improvement of nesfatin-1 levels in blood, brain, and fat tissues. CONCLUSIONS: As expected, curcumin administration caused significant improvement in fasting blood glucose levels. However, for the first time, we found marked improvements in nesfatin-1 levels in blood, brain, and fat tissues of type 2 DM rats. Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1.eninfo:eu-repo/semantics/closedAccessNesfatin-1CurcuminDiabetesStreptozotocinRatArticle253Q2Q21616162133629331WOS:000619780200052