Sönmez, G.M.Aytekin, A.Erten, R.Aldemir, M.N.Sakin, A.Esen, R.2025-05-102025-05-1020212651-453210.37047/jos.2020-805072-s2.0-85120793806https://doi.org/10.37047/jos.2020-80507https://hdl.handle.net/20.500.14720/2916Synchronous tumors are defined as two or more neoplasms either identified simultaneously or within 6 months after the initial diagnosis in the same patient. Herein, we report a 63-year-old man with synchronous gastric, rectal carcinoma, and in situ esophageal carcinoma who also had isolated esophageal metastasis from rectal carcinoma. The patient man was diagnosed with rectal carcinoma. 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography was performed for staging and demonstrated increased 18F-FDG uptake in the rectum lesion as well as in the gastric cardia and corpus. Esophagogastroduodenoscopy was performed. After performing multiple biopsies, histopathological examination of the esophageal specimen demonstrated metastatic adenocarcinoma, in situ esophageal squamous cell carcinoma, and gastric adenocarcinoma. Isolated esophageal metastasis from rectal cancer is a highly rare entity. Gastric and esophageal cancers can be observed simultaneously with colorectal cancers; therefore, we recommend performing routine esophagogastroduodenoscopy for patients diagnosed with colorectal cancer. © 2021 by Turkish Society of Medical Oncology.eninfo:eu-repo/semantics/openAccessEsophageal CancerGastric CancerIsolated MetastasisRectal CancerSynchronousArticle73N/AQ4159162491718