Demircioglu, SinanEkinci, OmerDogan, AliDemir, Cengiz2025-05-102025-05-1020180036-93302045-644110.1177/00369330187752402-s2.0-85046813519https://doi.org/10.1177/0036933018775240https://hdl.handle.net/20.500.14720/16072Demircioglu, Sinan/0000-0003-1277-5105; Demir, Cengiz/0000-0001-9856-184XThrombotic thrombocytopenic purpura is a rare condition that presents with microangiopathic haemolytic anaemia, thrombocytopaenia, fever, renal impairment and neurological symptoms. Plasma exchange is a lifesaving treatment for this condition. However, some cases may be non-responsive to plasma exchange, or loss of response may occur. Treatment options for refractory cases include high-dose corticosteroids, rituximab, vincristine, cyclophosphamide, splenectomy, bortezomib and N-acetylcysteine. We present a refractory case of thrombotic thrombocytopenic purpura responding to the last of these therapies.eninfo:eu-repo/semantics/closedAccessThrombotic Thrombocytopenic PurpuraRelapsedRefractoryN-AcetylcysteineArticle634Q3Q112212429739267WOS:000453465100006